Toxic for all living organisms, used on 80% of agricultural land, SDHIs pesticides Inhibit an enzyme : the Succinate DeHydrogenase

SDHIs in pictures

SDHIs are recognized as highly toxic

You have to equip yourself like cosmonauts to use them

But SDHIs are generously spread in nature

For some, direct contact leads to death (worms, fish)

Slow impregnation causes death of bees and tumors in rodents

It is found in food, drinks and hair

But the financial market of the SDHIs is flourishing and still growing

SDHIs: Questions Answers

ANSES : National (French) Agency for Food Safety, Environment and Labor


          In laboratories        …in stores

                   I poison    … and I heal




the whole story

the sequence of facts

The factual chronology since the launch of the alert, firstly to the health authorities (ANSES, National Agency for Sanitary Safety of Food, Environment and Labor), then, in front of their inertia, in the national press (Libération newspaper).

as for ANSES

Access to some of the documents generated by ANSES concerning the SDHIs and the detailed answers given when the need appeared to us to do so.

as for assemblies

You will find here references to the questions concerning the SDHIs raised by elected members following our alert, the authorities’ replies as well as a mention of the meetings we had to participate in about the SDHIs.

the science corner

the basics

A brief presentation of the mechanism by which SDHIs act and the reason of their toxicity for all living organisms.

research articles

The scientific data, as links or directly as articles, reporting the consequences of an inhibition of SDH in humans, in animals and illustrating the danger represented by mitochondriotoxic pesticides as SDHIs


A section referring to some echoes received from abroad concerning the use of SDHIs

Who are we

The scientists at the origin of the call concerning the dangers represented by the SDHIs (published in April 2018 in the newspaper Libération), Paule Bénit, PhD (Research Engineer IR2 INSERM, National Institute for Health and Medical Research) and Pierre Rustin, PhD (Research Director CE Emeritus at CNRS, National Center for Scientific Research), members of the Physiopathology and Mitochondrial Disease Therapy Team, of the Mixed Research Unit INSERM UMR 1141 (located at Robert Debré hospital in the 19th arrondissement of Paris), directed by Pierre Gressens, research director at INSERM and professor of fetal and neonatal neurology at King’s College in London.

the initial alert

Members of the CNRS (Malgorzata Rak, PhD, Research Fellow CR1, UMR 1141), INSERM (Judith Favier, PhD, Research Director DR2, UMR970 Cancerology, Georges-Pompidou European Hospital, Dominique Chrétien, PhD, Research Engineer IR2, UMR 1141); AP-HP (Public Assistance – Paris Hospitals; Anne-Paule Gimenez-Roqueplo, MD, PhD, Professor, Oncology, Georges-Pompidou European Hospital; UMR970; Manuel Schiff, MD, PhD, University Lecturer, Hospitaller Practitioner, UMR 1141) have joined the initial call to highlight the dangers of using SDHIs and calling for the suspension of their use under the precautionary principle..


You want to express your support or / and be informed about projects and progress, contact Pierre Rustin

We thank David Pavlowsky for his help in the realization of the site, Jorge Gallego for his re-readings, Alessia Catania, Céline Xiang Li, Malgorzata Rak, Amazigh Mokhtari, Jûrgen-Christoph Von Kleist-Retzow and Robert Lightowlers for the translations, Nicole Pavlowsky for her drawings and Jackie Duret for her photos.